N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-GAMMA-T-BUTOXYCARBONYL-D-ALPHA,GAMMA-DIAMINOBUTYRIC ACID
Fmoc-D-Dab(Boc)-OH
CAS: 114360-56-4
Molecular Formula: C24H28N2O6
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-GAMMA-T-BUTOXYCARBONYL-D-ALPHA,GAMMA-DIAMINOBUTYRIC ACID - Names and Identifiers
| Name | Fmoc-D-Dab(Boc)-OH |
| Synonyms | Fmoc-D-Dab(Boc)-OH RARECHEM BK PT 0248 Fmoc-D-Dab(Fmoc)-Oh FMOC-D-DAB(FMOC)-OH DI-FMOC-D-ALPHA,GAMMA-DIAMINOBUTYRIC ACID N-ALPHA-FMOC-N-GAMMA-BOC-D-DIAMINOBUTYRIC ACID N-ALPHA,GAMMA-DI-FMOC-D-ALPHA,GAMMA-DIAMINOBUTYRIC ACID N-ALPHA-N-GAMMA-BIS-(9-FLUORENYLMETHYLOXYCARBONYL)-D-2,4-DIAMINOPROPIONIC ACID N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-GAMMA-T-BUTYLOXYCARBONYL-D-2,4-DIAMINOBUTYRIC ACID (2R)-4-[(tert-butoxycarbonyl)amino]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}butanoic acid N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-GAMMA-TERT-BUTYLOXYCARBONYL-D-2,4-DIAMINOBUTYRIC ACID N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-GAMMA-T-BUTOXYCARBONYL-D-ALPHA,GAMMA-DIAMINOBUTYRIC ACID |
| CAS | 114360-56-4 |
| EINECS | 1533716-785-6 |
| InChI | InChI=1/C24H28N2O6/c1-24(2,3)32-22(29)25-13-12-20(21(27)28)26-23(30)31-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,26,30)(H,27,28)/t20-/m1/s1 |
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-GAMMA-T-BUTOXYCARBONYL-D-ALPHA,GAMMA-DIAMINOBUTYRIC ACID - Physico-chemical Properties
| Molecular Formula | C24H28N2O6 |
| Molar Mass | 440.49 |
| Density | 1.243±0.06 g/cm3(Predicted) |
| Boling Point | 670.9±55.0 °C(Predicted) |
| Flash Point | 359.6°C |
| Vapor Presure | 6.47E-19mmHg at 25°C |
| Appearance | Powder |
| Color | White |
| pKa | 3.79±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.575 |
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-GAMMA-T-BUTOXYCARBONYL-D-ALPHA,GAMMA-DIAMINOBUTYRIC ACID - Risk and Safety
| HS Code | 29215900 |
| Hazard Class | IRRITANT |
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-GAMMA-T-BUTOXYCARBONYL-D-ALPHA,GAMMA-DIAMINOBUTYRIC ACID - Introduction
N-alpha-Fmoc-N-gamma-Boc-D-Diaminobutyric acid is a compound commonly abbreviated as Fmoc-D-Arg(Pbf)-OH. It is a non-protein amino acid containing a protecting group with the following properties:
1. Appearance: Fmoc-D-Arg(Pbf)-OH is a colorless crystalline solid.
2. Solubility: Fmoc-D-Arg(Pbf)-OH can be dissolved in organic solvents (such as dimethyl sulfoxide, methanol).
3. Stability: Fmoc-D-Arg(Pbf)-OH is relatively stable in liquid state, but may decompose under high temperature and high humidity conditions.
Fmoc-D-Arg(Pbf)-OH is mainly used in chemical reactions of peptide synthesis and solid phase synthesis, and is commonly used in the synthesis of peptide sequences containing arginine (Arg) residues in the peptide chain. Its uses mainly include:
1. peptide synthesis: as a peptide synthesis starting reagent or increase arginine residues of peptide chain extension reagent.
2. Solid-phase synthesis: For use in solid-phase synthesis, polypeptides containing arginine residues are synthesized by a solid-phase synthesis strategy.
The method for preparing Fmoc-D-Arg(Pbf)-OH is mainly obtained by chemical synthesis, which generally includes the following steps:
1. Using L-glutamyl compound as starting material, the intermediate was synthesized by N-α protection and N-γ protection reaction.
2. The intermediate is hydrolyzed to remove the protecting group to obtain the Fmoc-D-Arg(Pbf)-OH.
In the process of using Fmoc-D-Arg(Pbf)-OH, the following safety precautions should be paid attention:
1. use should wear appropriate personal protective equipment, such as gloves and goggles.
2. Avoid contact with skin and eyes, and avoid inhaling dust or solution.
3. Operate in a sufficiently ventilated laboratory to avoid inhaling aerosols.
4. Storage Fmoc-D-Arg(Pbf)-OH should avoid direct sunlight and high temperature environment, keep dry.
1. Appearance: Fmoc-D-Arg(Pbf)-OH is a colorless crystalline solid.
2. Solubility: Fmoc-D-Arg(Pbf)-OH can be dissolved in organic solvents (such as dimethyl sulfoxide, methanol).
3. Stability: Fmoc-D-Arg(Pbf)-OH is relatively stable in liquid state, but may decompose under high temperature and high humidity conditions.
Fmoc-D-Arg(Pbf)-OH is mainly used in chemical reactions of peptide synthesis and solid phase synthesis, and is commonly used in the synthesis of peptide sequences containing arginine (Arg) residues in the peptide chain. Its uses mainly include:
1. peptide synthesis: as a peptide synthesis starting reagent or increase arginine residues of peptide chain extension reagent.
2. Solid-phase synthesis: For use in solid-phase synthesis, polypeptides containing arginine residues are synthesized by a solid-phase synthesis strategy.
The method for preparing Fmoc-D-Arg(Pbf)-OH is mainly obtained by chemical synthesis, which generally includes the following steps:
1. Using L-glutamyl compound as starting material, the intermediate was synthesized by N-α protection and N-γ protection reaction.
2. The intermediate is hydrolyzed to remove the protecting group to obtain the Fmoc-D-Arg(Pbf)-OH.
In the process of using Fmoc-D-Arg(Pbf)-OH, the following safety precautions should be paid attention:
1. use should wear appropriate personal protective equipment, such as gloves and goggles.
2. Avoid contact with skin and eyes, and avoid inhaling dust or solution.
3. Operate in a sufficiently ventilated laboratory to avoid inhaling aerosols.
4. Storage Fmoc-D-Arg(Pbf)-OH should avoid direct sunlight and high temperature environment, keep dry.
Last Update：2024-04-09 02:00:41
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Product Name: FMOC-D-DAB(FMOC)-OH Visit Supplier Webpage Request for quotationCAS: 114360-56-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-GAMMA-T-BUTOXYCARBONYL-D-ALPHA,GAMMA-DIAMINOBUTYRIC ACID
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丙酸正丁酯